The Drug Developer’s
Practical Navigator

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The hardest problem in biopharma is picking the right target.

Despite rapid biotechnological progress, up to 90% of drug candidates fail in the clinic. Poor choice of targets drives these failures through toxicity and lack of translational efficacy.

This is not for lack of information: we have a wealth of genetic and genomic evidence about targets that can mitigate these risks. Genomic evidence is associated with considerable increases in program success (~3x). Notable cases include PCSK9 (cholesterol), TYK2 (autoimmune disease), and TL1A (GI disorders). Yet this information is rarely used. Datasets are isolated, of uneven quality, and not easily accessible. A recent review has shown that despite demonstrable successes, only ⅓ of active drug programs use genomic evidence, relying instead on “gut feel” and “expert opinion.”

We are building a “Bloomberg for Biology”

It’s an intuitive software product enabling founders, executives, scientists, and investors to understand the genomic association of a target with disease, its biological context, the feasibility of drugging it, its potential safety risks, and the competitive landscape of clinical trials related to it.

By making these data easily accessible with clear provenance and traceable analytics, they can be used confidently by a variety of decision-makers without needing to hire and manage consultants or computational biologists. Fresnel enables assessing not only the causality of the target in disease and the risks it presents, but also how it can be approached and a sense of the commercial opportunity.

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Meet Fresnel.

Bloomberg for Biology
• Fresnel's tools are built to tackle the hardest problem in biopharma: target selection.
• Empower strategic decisions with effortless access to critical biological knowledge.
• Streamline target prioritization and due diligence with state-of-the-art analytics and real-time data.
• Get access to comprehensive genetic, genomic, and clinical data about a target, in a single hub.
• Gain confidence in your findings with Fresnel's transparent and traceable analytics.
GENETICS
Link Genes to Disease
• Prioritize targets with genetic links to disease, increasing the likelihood of clinical success.
• Identify which regions of the genome are associated with a disease of interest.
• View the primary sources of genetic evdience.
GENETICS
Find Off Target Effects
• Find safety risks using human genetics.
• Identify opportunities for indication expansion.
• Browse known molecular genetics and statistical genetics associations for any target.
KNOWN BIOLOGY
Get Smart Quick
• Capture key details about a target.
• Review biological details including function, genetics, and brief history.
KNOWN BIOLOGY
Map Gene Interactions & Pathways
• Understand who this target interacts with.
• View the functional pathways this target is involved in.
GENE EXPRESSION
Locate Your Target By Tissue & Cell Type
• Map how a gene is expressed across cells and tissues.
• Determine how to hit your target while avoiding potential liabilities.
• Identify common tissue and cell types where your target is and is not expressed.
GENE EXPRESSION
Distinguish Cell Types by Target
• Pinpoint genes that distinguish cell types of interest to enhance targeting.
• Ensure your target is expressed in the cell types you desire and understand where potential risks may lie.
CLINICAL TRIALS
When Was This Target Drugged?
• Map how and when drugs against your target have been tested in humans.
• Track the development timelines of all drugs in an indication.
CLINICAL TRIALS
What is the Competitive Landscape?
• Dive into individual studies in depth.
• Explore where a drug has been trialed in the past and what happened.
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